A SAMSON nyomán: statinintolerancia, nocebohatás, adherencia

Series of clinical studies proved the beneficial effect lipid lowering therapy on process atherosclerosis and frequency cardiovascular events, according to these it plays an awarded role in preventive treatment recommendations. In most recent European dyslipidemia guidelines a lower LDL-cholesterol target has been established. Despite many evidence guidelines’ recommendations, quality lipid-lowering also goal attainment rate is inadequate. What are reasons inertia? From patients’ side appearance different effects factor for decreasing their compliance. The statin intolerance believed occur 10-15% cases. Many patients complain muscle pain when taking statins, but actual relation with medications significantly less common than appears based symptoms. STOMP study was designed examine effect, naive occurrence myalgia group 80 mg atorvastatin 9.4%, placebo 4.6%. endpoint HOPE-3 study, incidence 5.8% case 10 rosuvastatin 4.7% group. According recently presented, very well-designed, randomized, double-blind SAMSON 90% complaints that statins not due drug effect. Improving adherence might be achieved through continuous education, use electronic devices, simplifying treatment. To attain better level reduction, attitude medical staff related should optimized.